Linköping University Post Print Vasomotor symptoms usually reappear after cessation of postmenopausal hormone therapy: a Swedish population-based study
نویسندگان
چکیده
218 words) Objective: To investigate to what extent vasomotor symptoms reappeared after cessation of postmenopausal hormone therapy (HT) in women who started HT due to hot flashes. Design: A cross-sectional postal survey. A validated questionnaire was sent to all women, 53-54 years old, living in Linköping, Sweden (n=1,733) including questions about menopause, HT and vasomotor symptoms. Pearsons chi-square test and logistic regression were used for statistical analyses. Results: Response rate after one reminder was 77.3 %. After omitting incomplete answers 72.9 % remained for analysis. In all 319 (25.3 %) women were current users of HT, 242 (19.2 %) previous users and 702 (55.6 %) were never users. Of the 242 previous users 165 (69 %) women stated that they had vasomotor symptoms before starting HT. Vasomotor symptoms recurred after cessation of HT in 143 of these 165 women (87 %). We found no significant difference in symptom recurrence in comparisons of the three groups based on usage of HT for 0-1, 2-4 or 5 years or more. Conclusions: The majority of women who had vasomotor symptoms when they initiated HT reported recurrence of symptoms after cessation of HT (87 %), although the flashes were usually reported to be less frequent and bothersome than before HT. Effective and safe treatment approaches for women with recurrence of vasomotor symptoms are needed.
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